journal self-citations removed) received by a journal's published documents during the three previous years. Frontiers in Immunology | Science Frontiers in Immunology Latest Journal's Impact IF 2022 The Impact Factor of Frontiers in Immunology has steadily increased over the years, reflecting the growing importance of immunology research. Chief Editors, Associate Editors and Review Editors are all listed with their names and affiliations on the Journal pages and are encouraged to publicly list their publication credentials. Fernando Corrales. The first analysis of the leukocyte transcriptomes provided an overview of the relative transcriptional changes occurring at 10 time points across the three phases of a space mission: PF, IF, and R. Astronauts leukocyte transcriptomes showed opposite directions of gene expression changes upon reaching the space environment compared to the return on Earth. It is published by Annual Reviews Inc.. Frontiers in Immunologyis a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. Expect on average14 weeksfrom submission to publication. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. 20 Nov 1987. Technical limitations onboard the ISS hampered sample acquisition, processing, and analysis. We measured gene expression through RNA sequencing of leukocytes and applied generalized linear modeling to assess differential expression across all 10 time points followed by the analysis of selected time points and functional enrichment of changing genes to identify shifts in biological processes. As part of the temporal analysis, independent filtering of genes using DESeq2 excluded genes with mean normalized read counts <45 resulting in a profile of 15,410 genes representing the expressed transcriptome across time. In this study, we investigated the effects of CB in the feed on growth performance, digestion and intestinal health of juvenile spotted sea bass. They have complete control over this. Our impact metrics reflect the power of research that is open to all. The 2020 Journal Impact Factors are based on citations in 2020 to articles published in 2018 and 2019. CiteScore covers all journal titles in Elsevier's Scopus database and is released once a year. Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL. Conclusion: The leukocytes transcriptome changes describe rapid adaptations in response to entering space followed by opposite changes upon returning to Earth. Considering the rapid changes of CD3 complex gene expression, adaptive immunity such as the response to foreign antigens is likely affected by changing microgravity environments, rather than innate immune systems (30). Int Immunol (2015) 27(7):35764. DS and OL participated in the statistical analysis. Libraries (125 pM) were multiplexed and sequenced with 100-base paired-end reads to a depth of ~50 million reads per sample using the Illumina NovaSeq 6000 System (Illumina, San Diego, CA, USA). Frontiers articles achieve high visibility and impact as a result of our promotion strategies. It is computed in the year 2022 as per its definition and based on Scopus data. The action you just performed triggered the security solution. 2023 Frontiers Media S.A. All rights reserved, Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders, Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders, Cytokines and Soluble Mediators in Immunity, International Union of Immunological Societies (IUIS). The Frontiers in Immunology is assigned the following International Standard Serial Numbers (ISSN): 16643224. The journals impact factor, a measure of the average number of citations received by articles published in the journal over a given period, varies yearly. (C) Dot plot displaying the gene ontology (GO) terms obtained from the overrepresentation analysis (ORA) of temporal gene clusters across all mission phases. But the impact factor works beyond this and shows that numbers are not absolute. The standard ISO4 abbreviation for the Frontiers in Immunology is Front. Frontiers in Immunology has an h-index of 190. The size of each dot is proportional to the enrichment factor (size scale) and the color represents the FDR adjusted p-values, where darker points have lower values (color scale). The entire calculation of the impact factor is based on a two-year period and consists of dividing the number of times that articles were cited by the number of articles that are citable. WebImpact. Borroto A, Lama J, Niedergang F, Dautry-Varsat A, Alarcon B, Alcover A. Transcript levels were reported as z-scores, which centered and scaled the normalized read counts for each gene by the mean and standard deviation across the 276 genes, ensuring comparable scaling and visualization for all genes. Both clusters converged toward average expression between ~2 and ~6 months in space. Principal component analysis (PCA) of all 72 samples passing RNA quality metrics (RIN 8.0). Over the course of the last 9 years, this journal has experienced varying rankings, reaching its highest position of 624 in 2016 and its lowest position of 1344 in 2018. doi: 10.4049/jimmunol.163.1.25, 29. Caution should be employed while interpreting journal impact factors and their ranks, and a measure of uncertainty should always be presented along with the point estimate. Your IP: WebFrontiers in Immunology. Library quality was assessed using the Agilent BioAnalyzer 2100, and 72 samples passed the quality metrics for sequencing including a concentration above 10 nM (Supplementary Figure1). Should it become clear that the Associate Editor has a conflict of interest or is unable to perform the peer-review timely and adequately, a new Associate Editor can be assigned to the manuscript by the Chief Editor, who has full control to intervene in the peer-review process at any time. Frontiers in Immunology | Articles Journal impact factors are indicative only when the evaluated research is absolutely standard concerning the journals used, an assumption that really makes any evaluation a bit excessive. Differential expression was measured using an integrated time-course analysis followed by a focused analysis of mission phase transition time points. Ranks #3 on Impact Factor 1.9 times the average in open-access journals in Immunology. When submitting a manuscript to Frontiers in Immunology, authors must * Correspondence: Pandiarajan M, Hargens AR. doi:10.1007/s00018-022-04531-8, 30. Received: 09 Apr 2023; Accepted: 27 Jun 2023. The gene AQP3 with changes in opposite directions at both phase transitions functions as a water and urea exit mechanism of antidiuresis in collecting duct cells a mechanism regulating body fluids (37). It is published by Frontiers Media S.A.. doi: 10.1152/japplphysiol.00789.2018, 36. The next characteristic of leukocyte transcriptome temporal changes observed was the transcriptional convergence toward average levels displaying no differential expression after 2 months of space exposure. Switzerland Figure4 lists the 100 genes along with a heatmap displaying the LFC values relative to PF for each gene. Article citations also increased by 50%, totaling two million. Sample principal component scores were calculated from the variance stabilizing transformation (VST) of normalized read counts for the 59,901 genes. Frozen blood samples were thawed at room temperature for ~15 min, and leukocytes layered on top of the gel were resuspended by gentle inversion of the tube. HOME PRIVACY POLICY FRONTIERSIN.ORG, 2021 Frontiers Media S.A. All Rights Reserved. Frontiers In Immunology Impact Factor J Appl Physiol (2019) 126(4):84253. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. Therefore, this sample was treated as a technical outlier and excluded from further analyses leaving 71 samples for analysis in silico. Frontiers Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. It is based on the idea that 'all citations are not created equal'. Using the BenjaminiHochberg correction for multiple comparisons, p-values with false discovery rate (FDR) <0.05 were considered statistically significant. The impact factor should be used while being vigilant to the many circumstances that affect citation rates, for example, the average number of citations in an average article. Fourteen astronauts, 11 men (46.7 7.3 years old) and three women (39.7 2.1 years old) consented to participating in the study on the temporal analysis of the leukocyte transcriptomes from blood samples collected throughout the three phases of their mission: pre-flight (PF), in-flight (IF), and return to Earth (R). What are some of the latest trends and developments in immunology research? With an Impact Factor of 5.511, Frontiers in Immunology is among the top 10 most-cited journals in its field WebWell, we all know that watch the numbers and higher will win. doi: 10.3174/ajnr.A6249, 3. Impact Factor Keywords: systemic lupus erythematosus, Gut Microbiota, Dysbiosis, Immune dysregulation, Cytokines. (2 years)). Although these cells have become the focus of intense research, a comprehensive understanding of the underlying regulatory networks that orchestrate CD4+ T cell function and activation is still incomplete. Total Journal's Impact IF Growth Rate (2011 - 2023) 986.2%. Frontiers in Immunology. The comparison of transcriptomes between PF and 1-year post-flight showed that the two gene clusters were reversed in expression. Z-scores represent the average normalized read counts for the 14 astronauts scaled across the 15,410 genes at each individual time-point. In contrast, egress to Earth is related to immune reactivation. Frontiers in Immunology | Vaccines and Molecular Therapeutics Only leading researchers acting as Associate Editors, who are not part of Frontiers staff, can make acceptance decisions based on reviews performed by external experts acting as Review Editors or reviewers. The reviewers are aided by an online standardized review questionnaire adopted to article types with the goal to facilitate rigorous evaluation according to objective criteria and the Frontiers Review Guidelines. Web 13 rows Immunology Impact Factor IF number of article detailed information and journal factor. Blood draws were taken at 10 different time points throughout astronaut missions; changes of interest to establish the onset of transcriptional convergence in space timed in-between blood draws may have been missed. Reviewer identity is protected at this stage to safeguard complete freedom of opinion. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. The acceptance rate/percentage of any academic journal/conference depends upon many parameters. The ISSN of Frontiers in Immunology is 16643224. Int J Mol Sci (2020) 21(24):132. doi: 10.1038/npjmgrav.2015.13, 9. C1 consisted mostly of protein-coding genes (68.8%), 19.4% long non-coding RNAs (lncRNA), and 11.7% genes coding for other various RNA biotypes (Figure2). doi:10.1074/jbc.M208999200, 38. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Bio-typing of gene RNA revealed distinct bio-type proportions of the two temporal gene clusters. The finding of genes responding to both the transition to and from space with decreased and then increased profile of changes that related to immune processes represents a novel finding. Editorial decision power is distributed in Frontiers, because we believe that many experts within a community should be able to shape the direction of science for the benefit of society. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccineassociated myocarditis. 9F008-140254). Cloudflare Ray ID: 7de34ab53c6d3a6d WebIn this review, the dysbiosis of gut microbiota in SLE, potential mechanisms linking gut microbiota and SLE, and immune dysregulation associated with gut microbiota in SLE are summarized. An ISSN is a unique code of 8 digits. Each point represents an astronaut RNA sample () and colors indicate the time-point for sample collection (). 9.8 CiteScore. For insight into the broader biological functions of the differentially expressed gene profiles, functional enrichment of leukocyte transcriptomes using two separate overrepresentation analyses (ORAs) (20) of gene ontology (GO) terms was performed: one is to assess the temporal effect across all time points using the differentially expressed gene clusters and the other is to assess the spaceflight phase transitions using the differentially expressed genes from the selective time-point comparisons. Analysis between PF and 1-year post-flight time points (PF vs. R5) revealed zero differentially expressed genes (Table2). We sought to characterize the molecular response involved by capturing changes in leukocyte transcriptomes from astronauts transitioning to and from long-duration spaceflight. Frontiers Reads were aligned to the publicly available human transcriptome and genome (GRCh38.84) using HISAT with default parameters (v2.0.13) (12). The overall rank of Annual Review of Immunology is 18. Investigators can request access to the astronaut data at jsc-lsda@mail.nasa.gov. Following the latest release of the Web of Science Group's Journal Citation Report (JCR) and Scopus' CiteScore, we have 46 journals with a Journal Impact Factor and 57 journals with a CiteScore. Cluster network of gene ontology (GO) terms was obtained from the phase-specific overrepresentation analysis (ORA) of 112 downregulated genes between PF and IF2 (A, B), and 135 upregulated genes between IF4 and R1 (D, E) with stacked bar plots (C, F) displaying the RNA Bio-type proportions for these genes. Transcriptional changes were found in multiple immune cell types including Peripheral Blood Mononuclear Cells (PBMCs), CD4 and CD8 T lymphocytes, and CD19 B lymphocytes. Therefore, reaching space promoted leukocyte gene expression related to basic housekeeping cell functionality as well as specific space adaptations like headward body fluid shifts leading to loss in plasma volume and hemoconcentration (38). These results shed light on immune modulation in space and highlight the major adaptive changes in cellular activity engaged to adapt to extreme environments. In 2020, article views and downloads increased by 62% over the previous year, totaling one billion. DOI: 10.1126/science.3685961. The Citation: Stratis D, Trudel G, Rocheleau L, Pelchat M and Laneuville O (2023) The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation. Colored lines, split violin, and box plots represent the profiles of temporal gene clusters identified through hierarchical clustering. doi: 10.1152/jappl.1996.81.1.105, 6. Frontiers PLOS One The temporal analysis was conceptually similar to analysis of variance (ANOVA) but instead represented an analysis of deviance (ANODEV) because DESeq2 estimates dispersion not variance. PloS One (2011) 6(7):e21800. The Euclidean distance was calculated between each of the 276 gene candidates using their z-scores scaled normalized read counts, which were then hierarchically clustered into the resulting tree dendrogram revealing two distinct gene clusters characterized by similar patterns of expression changes throughout the study.

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